|
KMID : 0604520000260020041
|
|
Journal of the Society of Cosmetic Scientists of Korea
2000 Volume.26 No. 2 p.41 ~ p.49
|
|
|
Regulation of Melanogenesis as Studied by Chemical Analysis of Melanins
|
|
Ito, Shosuke
|
|
|
Abstract
|
|
|
- Biochemical studies show that in the process of mixed melanogenesis, cysteinyldopas are produced first which are next oxidized to give pheomelanin. After all of the cysteine is consumed, eumelanin is then deposited on the preformed pheomelanin.
- In vitro and in vivo studies show that tyrosinase activity is the most important factor that regulates the switch of melanogenesis, with higher activities increasing melanogenesis, especially eumelanogenesis.
- In culturted melanocytes, the tyrosine to cysteine ratio is critical in determining the eumelanin to pheomelanin ratio.
- Our HPLC method to analyze eumelanin and pheomelanin has become a useful tool in the study of melanogenesis regulation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|